Fabrication and Characterization of PLA-PGA Orthopedic Implants.

نویسندگان

  • C M Agrawal
  • G G Niederauer
  • K A Athanasiou
چکیده

Fabrication methods and property characterization of polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers are reviewed. Both of these aliphatic polyesters belong to the a-hydroxy group and biodegrade in a physiological environment to monomeric acids, which are readily processed and excreted from the body. The physical and mechanical characteristics discussed include molecular weight, crystallinity, stress-strain behavior, permeability, and melting/glass transition temperatures. The most common methods of fabricating PLA-PGA materials into medical devices are described.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis and characterization of nHA-PLA composite coating on stainless steel by dip-coating process for biomedical applications

316L stainless steel is the most commonly used metallic material in the manufacture of orthopedic implants. To achive better properties metal implants often coated with biocomposites. A sol–gel method was used for coating of Poly lactic acid (PLA)/Hydroxyapatite nanopowder (nHA) on stainless steel 316L substrate. The X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) wer...

متن کامل

Technique to control pH in vicinity of biodegrading PLA-PGA implants.

This in vitro study was performed to examine if the pH decrease in the vicinity of degrading polylactic acid (PLA) and polyglycolic acid (PGA) polymers can be offset by incorporation of basic salts within PLA-PGA implants. It has been suggested that such pH lowering results in adverse effects, which may be responsible for biocompatibility concerns raised recently about PLA and PGA polymers. The...

متن کامل

Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges

Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable prop...

متن کامل

Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification with changes in PLA/PGA copolymer ratios.

This study determined the difference in rate of degradation between pure polymers of lactic acid (pla), glycolic acid (PGA), and various ratios of copolymers of these two substances. Fast-cured and slow-cured polyglycolide was compared with copolymers of glycolide/lactide intermixed in ratios of 75:25, 50:50, and 25:75, as well as pure polylactide. A total of 420 rats were implanted with carbon...

متن کامل

Rapid Manufacturing of Co-Cr-Mo Implants by Three-Dimentional Printing Process for Orthopedic Applications

     The fabrication of complex-shaped parts out of (wt %) Co-28Cr-6Mo alloy by three-dimensional printing (3DP) was studied using two grades of the alloy with average particle sizes of 20 and 75 μm. To produce sound specimens, 3DP processing parameters were tuned. The sintering behavior of the powders was characterized by the dilatometric analysis. Batch sintering in argon atmosphere at 1280 °...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Tissue engineering

دوره 1 3  شماره 

صفحات  -

تاریخ انتشار 1995